كتاب DNA Engineered Noble Metal Nanoparticles

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DNA Engineered Noble Metal Nanoparticles
Fundamentals and State of the ar of Nanobiotechnology
من سلسلة علم المواد المتقدمة
Advanced Material Series
Ignac Capek

ويتناول الموضوعات الأتية :

Contents
Acknowledgement ix
Preface xi
1 Introduction 1
2 Nucleic Acids 29
2.1 DNA/RNA Basics 29
2.2 Aptamers, Telomers and Oligonucleotides 50
2.3 Techniques and Approaches 63
2.4 DNA-Based Molecular Nanomachines 90
2.5 Peptide Nucleic Acid 104
2.6 Nanobiotechnology 112
3 Noble Metal Nanoparticles 121
3.1 Preparation and Modifcation 121
3.2 Optical and Physical Properties 137
3.3 Conjugates 144
4 DNA-Based Conjugates 149
4.1 General 149
4.2 Condensation 152
4.3 Conjugates 170
5 DNA-Noble Metal Nanoparticle Conjugates 173
5.1 General Approaches 173
5.2 DNA Monomers and Oligomers 178
5.2.1 Gold Nanoparticles 178
5.2.2 Silver Nanoparticles 207
5.3 Hybridization and Denaturation 224
5.3.1 General Background 224
5.3.2 Linkers and Probes 228
5.3.3 Particle Size and Shape 238
5.3.4 Termodynamics 252
5.3.5 Salt E?ect 262
5.3.6 Approaches 267
5.4 DNA Biotemplates 273viii Contents
6 DNA-Gold Nanoparticle Conjugates 281
6.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates 281
6.2 DNA One-Dimensional Gold Nanoparticle Conjugates 295
7 PNA-Noble Metal Nanoparticles Conjugates 315
7.1 PNA-Gold Nanoparticle Conjugates 315
7.2 PNA-Silver Nanoparticle Conjugates 328
8 DNA-Silver Nanoparticles Conjugates 335
9 Te Structure of DNA-Noble Metal Nanoparticles Conjugates 345
9.1 Confguration of DNA-Noble Metal
Nanoparticles Conjugates 345
9.2 Stabilization of DNA Conjugates 358
9.3 Nanostructures and Nanoconstructs 369
9.4 Colorimetric and Sensing Assays 385
10 Photochemical and Photophysical Events 403
10.1 Noble Metal Nanoparticles 403
10.2 DNA Nucleobases 406
10.3 DNA/PNA 417
10.4 DNA-Dyes Conjugates 429
10.5 DNA-AuNP-Dye Conjugates 443
10.6 DNA-Gold Nanoparticle Conjugates 455
10.7 DNA-AgNPs 465
10.8 Hot Gold Nanoparticles 475
11 Nanoparticle Terapeutics 481
11.1 Biodecorated Nanoparticle-Based Terapies 481
11.2 Photothermal Terapy 489
11.3 Cells 495
11.4 Gene Terapy 499
11.5 Blood Fluid E?ect 505
11.6 Other Application Approaches 507
12 Conclusion 515
Nomenclature 533
DNA Entities 545
Vocabulary and Defnitions 549
References 564
Index 63

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